Welcome to the Website of the Pancreatic Clinical Study Unit (PanCSU) at the Department of Surgery at the Technical University of Munich.

We have particular interest in improving the clinical management of surgical diseases of the pancreas, including pancreatic cancer, chronic pancreatitis, and pancreatic cysts. Our current focuses include, but are not limited to:

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1. Resection margin status and neural invasion
   Investigators: Demir IE, Jäger, Schorn, Pergolini
   Publications:
   Demir IE, Jäger C, Schlitter AM, et al. R0 Versus R1 Resection Matters after Pancreaticoduodenectomy, and Less after Distal or Total Pancreatectomy for Pancreatic Cancer. Ann Surg. 2018;268(6):1058–1068. doi:10.1097/SLA.0000000000002345.
2. Establishment of clinically useful patient databases for pancreatic disease
   Investigators: Jäger, Schorn, Pergolini, Göß, Demir IE
3. Mechanisms of pancreatic fistula formation after pancreatic surgery
   Investigators: Demir E, Jäger. Demir IE, Safak
   Publications:
   Tieftrunk E, Demir IE, Schorn S, et al. Pancreatic stump closure techniques and pancreatic fistula formation after distal pancreatectomy: Meta-analysis and single-center experience. PLoS One. 2018;13(6):e0197553. Published 2018 Jun 13. doi:10.1371/journal.pone.0197553
4. Clinical impact of neoadjuvant therapy in gastrointestinal cancers
   Investigators: Schorn, Jäger, Demir IE, Göß
   Publications: Schorn S, Demir IE, Haller B, et al. The influence of neural invasion on survival and tumor recurrence in pancreatic ductal adenocarcinoma - A systematic review and meta-analysis. Surg Oncol. 2017;26(1):105–115. doi:10.1016/j.suronc.2017.01.007 Schorn S, Demir IE, Reyes CM, et al. The impact of neoadjuvant therapy on the histopathological features of pancreatic ductal adenocarcinoma - A systematic review and meta-analysis. Cancer Treat Rev. 2017;55:96–106. doi:10.1016/j.ctrv.2017.03.003 Schorn S, Nitsche U, Demir IE, et al. The impact of surgically placed, intraperitoneal drainage on morbidity and mortality after pancreas resection- A systematic review & meta-analysis. Pancreatology. 2018;18(3):334–345. doi:10.1016/j.pan.2018.02.013 Schorn S, Demir IE, Samm N, et al. Meta-analysis of the impact of neoadjuvant therapy on patterns of recurrence in pancreatic ductal adenocarcinoma. BJS Open. 2018;2(2):52–61. Published 2018 Mar 30. doi:10.1002/bjs5.46
5. Impact of reconstruction techniques on the postoperative outcome after pancreatic surgery
   Investigators: Schorn, Demir IE, Jäger, Göß
   Publications:
   Schorn S, Demir IE, Vogel T, et al. Mortality and postoperative complications after different types of surgical reconstruction following pancreaticoduodenectomy-a systematic review with meta-analysis. Langenbecks Arch Surg. 2019;404(2):141–157. doi:10.1007/s00423-019-01762-5
6. Cystic tumors of the pancreas & Diabetes
   Investigators: Pergolini, Jäger, Demir IE, Schorn
   Publications: Pergolini I, Sahora K, Ferrone CR, et al. Long-term Risk of Pancreatic Malignancy in Patients With Branch Duct Intraductal Papillary Mucinous Neoplasm in a Referral Center. Gastroenterology. 2017;153(5):1284–1294.e1. doi:10.1053/j.gastro.2017.07.019

Team members

PD Dr. I. Ekin Demir	Carsten Jäger, MPH	Dr. Stephan Schorn	Dr. Ilaria Pergolini
PI	Clinical Study Coordinator	Project Leader,Head of Study Design	Project Leader

Dr. R. Göß	Dr. Elke Demir
Project Leader	Project Leader

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We thank you for your interest in our research.

Ihsan Ekin Demir, MD, PhD

Principal Investigator
PanCSU